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Priv.-Doz. Dr.rer.nat. Souvik Kusari – Head of Chemical Microbiology

Priv.-Doz. Dr.rer.nat. Souvik Kusari – Head of Chemical Microbiology Foto von Priv.-Doz. Dr.rer.nat. Souvik Kusari

Telefon
(+49)231 755-4086

Fax
(+49)231 755-4084

Adresse

Technische Universität Dortmund
Analytische Chemie und Umweltchemie (INFU)
Otto-Hahn-Straße 6
44227 Dortmund
Deutschland

Campus Adresse
Campus Nord
Chemiegebäude

Raum C2-06-702

Publications

2017

Publications

1. Li, G.; Kusari, S.*; Golz, C.; Strohmann, C.; Spiteller, M.* (2017):
Epigenetic modulation of endophytic Eupenicillium sp. LG41 by a histone deacetylase inhibitor for production of decalin-containing compounds
Journal of Natural Products, 80,983-988. [*Corresponding authors] [PDF]

Eupenicillium

2. Eckelmann, D.; Kusari, S.*; Spiteller, M.* (2017):
Spatial profiling of maytansine during the germination process of Maytenus senegalensis seeds
Fitoterapia,119,108-114. [*Corresponding authors][PDF]

Seedling

3. Kyekyeku, J. O.; Kusari, S.*; Adosraku, R. K.; Bullach, A.; Golz, C.; Strohmann, C.; Spiteller, M.* (2017):
Antibacterial secondary metabolites from an endophytic fungus, Fusarium solani JK10
Fitoterapia, 119, 108-114. [*Corresponding authors][PDF]

endophytic_fungus

4. Kusari, S.*; Kusari, P.; Spiteller, M.* (2017):
Novel insights in plant-endophyte interactions
In: Chemical Biology of Natural Products, Newman, D. J.; Cragg, G. M.; Grothaus, P. G. (eds.), CRC Press, Taylor & Francis Group, USA. In Press. [*Corresponding authors]

4-Cover

5. Bedane, K. G.; Kusari, S.; Bullach, A.; Masesane, I. B.; Mihigo, S. O.; Spiteller, M.; Majinda, R. R. T. (2017):
Chemical constituents of the root bark of Erythrina droogmansiana
Phytochemistry Letters,20,84-88.[PDF]

5-HPLC

6. Nigutová, K.#,*; Kusari, S.#,*; Sezgin, S.; Petijová, L.; Henzelyová, J.; Bálintová, M.; Spiteller, M.; Čellárová, E. (2017):
Chemometric evaluation of hypericin and related phytochemicals in 17 in vitro cultured Hypericum species, hairy root cultures and hairy root-derived transgenic plants
Journal of Pharmacy and Pharmacology, accepted. [#Joint first authors; *Corresponding authors]

6-hypericin

7. Kusari, P.; Kusari, S.; Spiteller, M.; Kayser, O. (2017):
Cannabis endophytes and their application in breeding and physiological fitness
In: Cannabis sativa L.: Botany and Biotechnology, Chandra, S.; Lata, H.; ElSohly, M. A. (eds.), Springer International Publishing AG, pp. 419-437. [PDF]

7-Cannabis_sativa


Posters

1. Eckelmann, D.; Kusari, S.; Spiteller, M. (2017):
Spatial chemo-profiling of antineoplastic maytansinoids in Putterlickia pyracantha by MALDI-imaging-HRMS
At the 10th Tag der Chemie (Chemistry Day), Department of Chemistry and Chemical Biology, TU Dortmund, Germany; dated 24 Feb 2017.


Lectures

1. Kusari, S. (2017):
Chemical ecology of plant-associated endophytic microorganisms
At the Colloquium of the Institute of General Botany and Plant Physiology, Jena School for Microbial Communication (JSMC), Friedrich Schiller University, Jena, Germany; dated 31 Jan 2017.

2. Kusari, S. (2017):
Hiding in plain sight: Plant-associated endophytic microorganisms and their incredible biosynthetic feats
At the Department of Microbe-Plant Interactions, University of Bremen, Bremen, Germany; dated 27 Jan 2017

2016

Publications

1. Eckelmann, D.; Kusari, S.; Spiteller, M. (2016)
" Occurrence and spatial distribution of maytansinoids in Putterlickia pyracantha, an unexplored resource of anticancer compounds"
Fitoterapia, 113, 175-181

2. Li, G.; Kusari, S.; Golz, C.; Strohmann, C.; Spiteller, M. (2016)
"Three Cyclic Pentapeptides and a Cyclic Lipopeptide Produced by Endophytic Fusarium decemcellulare LG53"
RSC Advances 2016, 6, 54092-54098

3. Wang, W.-X.; Kusari, S.; Spiteller, M. (2016):
"Unraveling the chemical interactions of fungal endophytes for exploitation as microbial factories", In Purchase, D. (ed.) Fungal Applications in Sustainable Environmental Biotechnology, Springer Nature, London, in press.

4. Wang, W.-X.; Kusari, S.; Laatsch, H.; Golz, C.; Kusari, P.; Strohmann, C.; Kayser, O.; Spiteller, M. (2016):
"Antibacterial azaphilones from an endophytic fungus Colletotrichum sp. BS4"
Journal of Natural Products, 79, 704-710.
download PDF

5. Teponno, R. B.; Kusari, S.; Spiteller, M. (2016):
"Recent advances in research on lignans and neolignans"
Natural Product Reports, 33, 1044-1092
download PDF

6. Oppong Kyekyeku, J.; Kusari, S.; Adosraku, R. K.; Zühlke, S.; Spiteller, M. (2016):
"Prenylated 2- arylbenzofuran derivatives with potent antioxidant properties from Chlorophora regia (Moraceae)"
Fitoterapia, 108, 41-47.

7. Kusari, S.; Tatsimo, S. J. N.; Zühlke, S.; Spiteller, M. (2016):
"Synthetic origin of tramadol in the environment"
Angewandte Chemie International Edition, 55, 240-243; Hot Paper; featured on Back Cover. [Angewandte Chemie 2016, 128, 248-251].

8. Kusari, S.; Spiteller, M. (2016):
"The promise of endophytic fungi as sustainable resource of biologically relevant pro- drugs: A focus on Cameroon"
In Deshmukh, S. K.; Misra J. K.; Tewari J. P.; Tamas P. (eds.) Fungi: Applications and Management Strategies, CRC Press, Taylor & Francis Group, USA, 1-13.

9. Kusari, P.; Kusari, S.; Eckelmann, D.; Zühlke, S.; Kayser, O.; Spiteller, M. (2016):
"Cross-species biosynthesis of maytansine in Maytenus serrata"
RSC Advances, 6, 10011-10016.
download PDF

10. Bedane, K. G.; Kusari, S.; Masesane, I. B.; Spiteller, M.; Majinda, R. R. T. (2016):
"Flavanones of Erythrina livingstoniana with antioxidant properties"
Fitoterapia, 108, 48-54

Posters

1.Wang, W.-X., Kusari, S.; Kusari, P.; Kayser, O.; Spiteller, M. (2016):
" An endophytic fungus Phyllosticta capitalensis harboring uncultivable endosymbiotic bacterium Herbaspirillum sp. produces lactam-fused 4-pyrones",
At the 9th Joint Natural Products Conference 2016 (ASP, GA, PSE, AFERP, JSP and SIF); venue: Copenhagen, Denmark; dated: 24-27 July 2016

2. Li, G., Kusari, S.; Laatsch, H.; Golz, C.; Strohmann, C.; Spiteller, M. (2016):
"Decalin-containing polyketides with antibacterial activities from an endophytic fungus, Eupenicillium sp. LG41",
At the 9th Joint Natural Products Conference 2016 (ASP, GA, PSE, AFERP, JSP and SIF); venue: Copenhagen, Denmark; dated: 24-27 July 2016

3. Kusari, S.; Kusari, P.; Eckelmann, D.; Zühlke, S.; Kayser, O.; Spiteller, M. (2016):
"New insights in plant-endophyte communication: maytansine as an example",
At the Annual Conference of the Association for General and Applied Microbiology 2016 [Jahrestagung der Vereinigung für Allgemeine und Angewandte Mikrobiologie (VAAM) 2016]; venue: Jena, Germany; dated: 13–16 March 2016.

4. Kusari, S.; Kusari, P.; Eckelmann, D.; Zühlke, S.; Kayser, O.; Spiteller, M. (2016):
"Cross-species biosynthesis of maytansine in Maytenus serrata plants",
At the 28. Irseer Naturstofftage; venue: Schwäbisches Tagungs- und Bildungszentrum Kloster Irsee; dated: 24-26th Feb 2016.

5. Eckelmann, D.; Kusari, S.; Kusari, P.; Zühlke, S.; Kayser, O.; Spiteller, M. (2016):
"Investigation of maytansine biosynthesis in Maytenus serrata and identification of precursors by HPLC- HRMSn".
At the 9th Tag der Chemie (Chemistry Day), Department of Chemistry and Chemical Biology, TU Dortmund, Germany; dated 19 February 2016".

Lectures

1. Kusari, S. (2016):
"Plant-endophyte communication for biosynthesis of bioactive natural products: maytansine as an example",
At the Royal Society of Chemistry (RSC) Conference – “Bioactive Natural Products: translating promise into practice”, St Catherine’s College, University of Oxford, United Kingdom; dated 11-13 July 2016

2. Kusari, S. (2016):
"Novel insights into plant-endophyte communication: maytansine as an example",
At the 9th Joint Natural Products Conference 2016 (ASP, GA, PSE, AFERP, JSP and SIF); venue: Copenhagen, Denmark; dated: 24-27 July 2016


3. Kusari, S. (2016):
"Hiding in plain sight- Endophytes and their incredible biosynthetic feats",
At the Department of Engineering Sciences, Oxford University Begbroke Science Park, University of Oxford, Oxford, United Kingdom; dated 29 Jan 2016.


4. Kusari, S. (2016):
"Hiding in plain sight: Endophytes and their incredible biosynthetic feats",
At the Department of Plant Sciences, University of Oxford, Oxford, United Kingdom; dated 26 Jan 2016.

2015

Publications

1. Wang, W.-X.; Kusari, S.; Sezgin, S.; Lamshöft, M.; Kusari, P.; Kayser, O.; Spiteller, M. (2015):
"Hexacyclopeptides secreted by an endophytic fungus Fusarium solani N06 act as crosstalk molecules in Narcissus tazetta"
Applied Microbiology and Biotechnology, 99, 7651-7662.

2. Mireku, E. A.; Kusari, S.; Eckelmann, D.; Mensah, A. Y.; Talontsi F. M.; Spiteller, M. (2015):
"Anti- inflammatory tirucallane triterpenoids from Anopyxis klaineana Pierre (Engl.), (Rhizophoraceae)"
Fitoterapia, 106, 84-91

3. Li, G.; Kusari, S.; Kusari, P.; Kayser, O.; Spiteller, M. (2015):
"Endophytic Diaporthe sp. LG23 produces a potent antibacterial tetracyclic triterpenoid"
Journal of Natural Products, 78, 2128-2132.

4. Kusari, S.; Sezgin, S.; Nigutova, K.; Cellarova, E.; Spiteller, M. (2015):
"Spatial chemo- profiling of hypericin and related phytochemicals in Hypericum species using MALDI- HRMS imaging"
Analytical and Bioanalytical Chemistry, 407, 4779-4791 [Topical Collection: Mass Spectrometry Imaging].

5. Kusari, P.; Kusari, S.; Spiteller, M.; Kayser, O. (2015):
"Implications of endophyte- plant crosstalk in light of quorum responses for plant biotechnology"

Applied Microbiology and Biotechnology, 99, 5383-5390.

6. Bedane, K. G.; Kusari, S.; Eckelmann, D.; Masesane, I. B.; Spiteller, M.; Majinda, R. R. T. (2015):
"Erylivingstone A- C with antioxidant and antibacterial activities from Erythrina livingstoniana"
Fitoterapia, 105, 113-118.

Posters

1. Wang, W.-X.; Kusari, S.; Sezgin, S.; Lamshöft, M.; Kusari, P.; Kayser, O.; Spiteller, M. (2015):
"Endophytic Fusarium solani secretes hexacyclopeptides to communicate with an associated endophytic bacterium",
At the 6th Junges Chemie Symposium Ruhr (JCS Ruhr); venue: Universität Essen; dated: 17 September 2015.

2. Li, G.; Kusari, S.; Spiteller, M. (2015):
"Paraconic acids and alkylitaconic acids from endophytic Eupenicillicum sp. LG41",
At the 6th Junges Chemie Symposium Ruhr (JCS Ruhr); venue: Universität Essen; dated: 17 September 2015.

Lectures

1. Spiteller, M.; Kusari, S.; Tatsimo, S. J. N.; Zühlke, S. (2015):
"Stable isotope analysis and 14C- AMS confirming synthetic origin of tramadol in environmental samples",
At the International Isotope Society- Central European Division(IIS- CED) Workshop, Bad Soden, Germany; dated 1- 2 October 2015.

2. Kusari, S.; Lamshöft, M.; Kusari, P.; Gottfried, S.; Zühlke, S.; Hentschel, U.; Kayser, O.; Spiteller, M. (2015):
"Hiding in plain sight, root endophytic community is the ‘true’ producer of maytansine in Putterlickia plants",
At the Annual Conference of the Association for General and Applied Microbiology [Jahrestagung der Vereinigung für Allgemeine und Angewandte Mikrobiologie (VAAM)]; venue: Marburg, Germany; dated: 01–04 March 2015.

3. Kusari, S. (2015):
"Endophytes: mysterious organisms under the skin of plants",
At the Gesellschaft Deutscher Chemiker E.V. (GDCh) Kolloquium, Ortsverband Dortmund [German Chemical Society Colloquium]; venue: TU Dortmund, Germany; dated: 20 April 2015.

4. Kusari, P.; Kusari, S.; Spiteller, M.; Kayser, O. (2015):
"Endophytes harbored in Cannabis sativa L. are experts in antivirulence",
At the 8th Tag der Chemie (Chemistry Day), Faculty of Chemistry and Chemical Biology, TU Dortmund, Germany; dated 13 February 2015.

2014

Publications

1. Li, G.; Kusari, S.; Spiteller, M. (2014):
"Natural products containing ‘decalin’ motif in microorganisms"
Natural Product Reports, 31, 1175-1201 [RSC Gold for Gold Open Access Article].
download PDF

2. Li, G.; Kusari, S.; Lamshöft, M.; Schüffler, A.; Laatsch, H.; Spiteller, M. (2014):
"Antibacterial secondary metabolites from an endophytic fungus, Eupenicillium sp. LG41"
Journal of Natural Products, 77, 2335-2341.

3. Laurice Bracine, C.; Kouam, S.; Lamshöft, M.; Kusari, S.; Talontsi, F.; Ngadjui, B. T.; Spiteller, M. (2014):
"Isolation and characterization of six new labdane diterpenes and one new pregnane steroid of Turraeanthus africanus"
Phytochemistry, 103, 137-144.

4. Kusari, S.; Singh, S.; Jayabaskaran, C. (2014):
"Rethinking production of Taxol (paclitaxel) using endophyte biotechnology" Trends in Biotechnology, 32, 304-311.

Trends in Biotechnology, 32, 304-311

5. Kusari, S.; Singh, S.; Jayabaskaran, C. (2014):
"Biotechnological potential of plant-associated endophytic fungi:hope versus hype"
Trends in Biotechnology, 32, 297-303.

6. Kusari, S.; Lamshöft, M.; Kusari, P.; Gottfried, S.; Zühlke, S.; Louven, K.; Hentschel, U.; Kayser, O.; Spiteller, M. (2014):
"Endophytes are hidden producers of maytansine in Putterlickia roots"
Journal of Natural Products, 77, 2577-2584 (ACS Editors Choice article; C&EN magazine-Dec 2014 edition; 2014 Arthur E. Schwarting Award from American Society of Pharmacognosy/ Journal of Natural Products).

7. Kusari, P.; Spiteller, M.; Kayser, O.; Kusari, S. (2014):
"Recent advances in research on Cannabis sativa L. endophytes and their prospect for the pharmaceutical industry"
In Kharwar, R. N. et al. (eds.) Microbial Diversity and Biotechnology in Food Security, Springer, 3-15.

8. Kusari, P.; Kusari, S.; Spiteller, M.; Kayser, O. (2014):
"Biocontrol potential of endophytes harbored in Radula marginata (liverwort) from the New Zealand ecosystem"
Antonie van Leeuwenhoek Journal of Microbiology, 106, 771-788.

9. Kusari, P.; Kusari, S.; Lamshöft, M.; Sezgin, S.; Spiteller, M.; Kayser, O. (2014):
"Quorum quenching is an antivirulence strategy employed by endophytic bacteria"
Applied Microbiology and Biotechnology, 98, 7173-7183.

10. Jouda, J.-B.; Kusari, S.; Lamshöft, M.; Talontsi, F.M. ; Meli C. D.; Wandji J.; Spiteller, M. (2014):
"Penialidins A-C with strong antibacterial activities from Penicillium sp., an endophytic fungus harboring leaves of Garcinia nobilis"
Fitoterapia, 98, 209-214.

11. Kusari, S.; Tatsimo, S. J. N.; Zühlke, S.; Talontsi, F. M.; Kouam, S. F.; Spiteller, M. (2014):
"Tramadol – a true natural product?"
Angewandte Chemie International Edition, 53, 12073-12272; VIP - Very Important Paper. [Angewandte Chemie 126, 12269-12272].

Posters

1. Li, G.; Kusari, S.; Spiteller, M. (2014):
"Eupenicillium sp. LG41, an endophytic fungus harbored in the medicinal plant Xanthium sibiricum produces new antimicrobial pro-drugs",
At the 7th Tag der Chemie (Chemistry Day), the Faculty of Chemistry, TU Dortmund, Germany; dated 7 February 2014.

Lectures

1. Kusari, S. (2014):
"Hiding in plain sight, endophytic microorganisms exhibit incredible biosynthetic feats",
At the Department of Genetics, Faculty of Science, Institute of Biology and Ecology, Pavol Jozef Šafárik University in Košice, Slovakia; dated 27 November 2014 (Invited lecture) .

2013


Publications

1. Sulimma, L.; Bullach, A.; Kusari, S.; Lamshöft, M.; Zühlke, S.; Spiteller, M. (2013):
"Enantioselective degradation of the chiral fungicides Metalaxyl and Furalaxyl by Brevibacillus brevis"
Chirality, 25(6), 336-340.

2. Kusari, S.; Pandey, S. P.; Spiteller, M. (2013):
"Untapped mutualistic paradigms linking host plant and endophytic fungal production of similar bioactive secondary metabolites"
Phytochemistry, 91, 81-87; Dedicated to memoriam of late Prof. Dr. Meinhart H. Zenk (Meinhart H. Zenk Special Memorial Issue of Phytochemistry).

3. Kusari, P.; Kusari, S.; Spiteller, M.; Kayser, O. (2013):
"Endophytic fungi harbored in Cannabis sativa L.: Diversity and potential as biocontrol agents against host plant-specific phytopathogens"
Fungal Diversity, 60, 137-151.

Posters

1. Kusari, S.; Lamshöft, M.; Spiteller, M. (2013):
"Chemical basis of cost-benefit tradeoffs between endophytic microorganisms and interacting organisms leading to biosynthesis of bioactive natural products"
At the 6th Tag der Chemie (Chemistry Day), the Faculty of Chemistry, TU Dortmund, Germany; dated 1 February 2013.

Lectures

1. Kusari, S. (2013):
"Biotechnological potential of plant-associated endophytic fungi: hope versus hype"
At the International Conference on Advances in Biotechnology and Bioinformatics (ICABB 2013) and X Convention of Biotech Research Society of India, Pune, India; dated 25-27 November 2013.

2. Kusari, S. (2013):
"Crosstalk between endophytic microorganisms and their hosts producing bioactive natural products"
At the Chemical Biology Science Meeting, Chemistry Research Laboratory (CRL), Department of Chemistry, University of Oxford, Oxford, United Kingdom; dated 15 May 2013 (Invited Lecture) .

3. Kusari, S. (2013):
"Endophytic fungal treasure troves- marvels under the skin of plants"
At the Department of Plant Sciences, University of Oxford, Oxford, United Kingdom; dated 7 May 2013 (Invited Lecture) .

4. Kusari, S. (2013):
"Endophytic fungal treasure troves: marvels under the skin of plants"
At the James Hutton Institute (JHI), Dundee, Scotland, United Kingdom; dated 30 April 2013 (Invited Lecture) .

5. Kusari, S. (2013):
"Endophytic fungi, microbial factories of pharmaceutically relevant pro-drugs: An Indian perspective of a global challenge"
At the Department of Biochemistry, Indian Institute of Science, IISc, Bangalore, India; dated 21 January 2013 (Invited Lecture) .

6. Kusari, S. (2013):
"Interspecies and multispecies crosstalk: Harnessing the biotechnological potential of plant- associated endophytic fungal treasure troves"
At the Department of Biotechnology, Indian Institute of Technology, Kharagpur, IIT- Kgp, India; dated 18 January 2013 (Invited Lecture) .

7. Kusari, S. (2013):
"Endophyte biotechnology: harnessing the pharmaceutical potential of plant-associated fungal treasure troves"
At the School of Natural Product Studies, Jadavpur University, Kolkata, India; dated 17 January 2013 (Invited Lecture) .

8. Kusari, S. (2013):
"Chemical basis of cost-benefit reciprocity of fungal endophytes leading to biologically relevant natural products"
At the Department of Biological Sciences, Indian Institute of Science Education and Research Kolkata, IISER-K, West Bengal, India; dated 16 January 2013 (Invited Lecture) .

9. Kusari, P.; Lamshöft, M.; Kusari, S.; Spiteller, M.; Kayser, O. (2013):
"Profiling of quorum sensing response and biocontrol potential of endophytic bacteria harbored in Cannabis sativa L."
At the Annual Conference of the Association for General and Applied Microbiology (VAAM); venue: Bremen, Germany; dated 10-13 March, 2013.

10. Kusari, P.; Kusari, S.; Spiteller, M.; Kayser, O. (2013):
"Biochemical fingerprinting of endophytes harbored in Radula marginata that confer plant fitness benefits"

At the 61st International Congress and Annual Meeting of the Society for Medicinal Plant and Natural Product Research (GA), Münster, Germany; dated Sept 2013.

2012

Publications

1. Kusari, S.; Verma, V. C.; Lamshöft, M.; Spiteller, M. (2012):
"An endophytic fungus from Azadirachta indica A. Juss. that produces azadirachtin"
World Journal of Microbiology and Biotechnology, 28, 1287-1294.

2. Kusari, S.; Spiteller, M. (2012):
"Camptothecin: recent advances in plant-endophyte research"
In (ed.) Patro, L. R. Natural Resources Conservation and Management, Manglam Publications, New Delhi, India, pp. 1-32.

3. Kusari, S.; Spiteller, M. (2012):
"Metabolomics of endophytic fungi producing associated plant secondary metabolites: progress, challenges and opportunities"
In (ed.) Roessner, U. Metabolomics, InTech, ISBN 978-953-51-0046-1, pp. 241-266.

4. Kusari, S.; Hertweck, C.; Spiteller, M. (2012):
"Chemical ecology of endophytic fungi: origins of secondary metabolites"
Chemistry & Biology, 19, 792-798

5. Kouam, S. F.; Kusari, S.; Lamshöft, M.; Tatuedom, O. K.; Spiteller, M. (2012):
"Sapelenins G- J, acyclic triterpenoids with strong anti- inflammatory activities from the bark of the Cameroonian medicinal plant Entandrophragma cylindricum"
Phytochemistry, 83, 79-86.

Posters

1. Sulimma, L.; Bullach, A.; Kusari, S.; Lamshöft, M.; Zühlke, S.; Spiteller, M. (2012):
"Enantioselective biodegradation of Metalaxyl in soil"
At the 5th. "Tag der Chemie" (Chemistry Day); organized by the Faculty of Chemistry, TU Dortmund, venue: TU Dortmund; dated February 03, 2012.


2. Kusari, S.; Talontsi Mouafo, F.; Zühlke, S.; Spiteller, M.; Kouam, S.; Kuigoua, G.; (2012):
"Bioprospecting for new antibacterial and inflammatory lead compounds from endophytic fungi harbored in Cameroonian medicinal plants from the Dja rainforest and Mount Cameroon"
At the DAAD Kick- off meeting "Welcome to Africa" initiative; venue: Bonn, Germany; dated: 12 March 2012.

3. Kusari, S.; Spiteller, M. (2012):
"Endophytic fungi, miracles under the skin of plants"
At the COST Action workshop 'Current aspects of European endophyte research' of the COST Action FA1103: Endophytes in Biotechnology and Agriculture; venue: Reims, France; dated: 28-30 March 2012.

4. Kusari, S.; Spiteller, M. (2012):
"Endophytic fungi, the microbial factories of associated plant secondary metabolites: Camptothecin as an example"
At the Annual Conference of the Association for General and Applied Microbiology [Jahrestagung der Vereinigung für Allgemeine und Angewandte Mikrobiologie (VAAM)]; venue: Tübingen, Germany; dated: 18–21 March 2012.

5. Kusari, P.; Kusari, S.; Spiteller, M.; Kayser, O. (2012):
"Endophytic diversity of pharmaceutically important Cannabis sativa"
At the International Congress on Natural Products Research (ICNPR 2012), the 8th Joint Meeting of AFERP, ASP, GA, PSE and SIF; venue: New York, USA; dated: 28 July 2012 - 1 August 2012.

6. Kusari, P.; Kusari, S.; Spiteller, M.; Kayser, O. (2012):
"Phylogenetic study of endophytes harbored in Cannabis sativa"
At the COST Action workshop 'Current aspects of European endophyte research' of the COST Action FA1103: Endophytes in Biotechnology and Agriculture; venue: Reims, France; dated: 28-30 March 2012.

Lectures

1. Kusari, S.; Spiteller, M. (2012):
"Endophyte research Quo Vadis?"
At the International Conference on Mycology and Plant Pathology. "Biotechnological Approaches" (ICMPB 2012), Varanasi, India, 27-29 February 2012 (Invited Lecture, plus Co-chair of a session, and Judge of two Poster Presentation sessions) .

2. Kusari, S.; Spiteller, M. (2012):
"Endophytic fungi, ignored treasures in traditional medicine"
At the 12th International Congress of Ethnopharmacology. "Traditional Medicines and Globalization-The Future of Ancient Systems of Medicine" (ISE 2012), Kolkata, India, 17-19 February 2012 (Plenary Lecture) .

2011

Publications

1. Kusari, S.; Zühlke, S.; Spiteller, M. (2011):
"Effect of Artificial Reconstitution of the Interaction between the Plant Camptotheca acuminata and the Fungal Endophyte Fusarium solani on Camptothecin Biosynthesis"
Journal of Natural Products, 74, 764-775.

2. Kusari, S.; Zühlke, S.; Spiteller, M. (2011):
"Correlations between camptothecin and related metabolites in Camptotheca acuminata reveal similar biosynthetic principles and in planta synergistic effects"
Fitoterapia, 82, 497-507.

3. Kusari, S.; Zühlke, S.; Spiteller, M. (2011):
"Chemometric evaluation of the anti-cancer pro-drug podophyllotoxin and potential therapeutic analogues in Juniperus and Podophyllum species"
Phytochemical Analysis, 22, 128-143.

4. Kusari, S.; Spiteller, M. (2011):
"Review of the present status and future promise of hypericin, a photodynamic antidepressant"
In (ed.) Patro, L. R. Bioresources Conservation and Management, Sonali Publications, New Delhi, India, pp. 1-22.

5. Kusari, S.; Spiteller, M. (2011):
"Are we ready for industrial production of bioactive plant secondary metabolites utilizing endophytes?"
Natural Product Reports, 28, 1203-1207.

6. Kusari, S.; Kosuth, J.; Cellarova, E.; Spiteller, M. (2011):
"Survival- strategies of endophytic Fusarium solani against indigenous camptothecin biosynthesis"
Fungal Ecology, 4, 219-223.

7. Awouafack, M.; Spiteller, P.; Lamshöft, M.; Kusari, S.; Ivanova, B.; Tane, P.; Spiteller, M. (2011):
"Antimicrobial Isopropenyl-dihydrofuranoisoflavones from Crotalaria lachnophora"
Journal of Natural Products, 74, 272-278.

Posters

1. Kusari, S.; Lamshöft, M.; Zühlke, S.; Spiteller, M. (2011):
"Plant-specific bioactive secondary metabolites produced by associated endophytic fungi"
The 4th. "Tag der Chemie" (Chemistry Day); organized by the Faculty of Chemistry, TU Dortmund; venue: TU Dortmund; dated February 04, 2011.

Lectures

1. Spiteller, M.; Kusari, S.; Lamshöft, M.; Zühlke, S. (2011):
"Endophytische Pilze – eine Quelle zur industriellen Produktion von bioaktiven Stoffen?"
Albert-Ludwigs-Universität Freiburg, Institut für Pharmazeutische Wissenschaften, Lehrstuhl für Pharmazeutische Biologie und Biotechnologie, Freiburg, Germany; dated 13 July, 2011

2010


Publications

1. Lamshöft, M.; Zühlke, S.; Sukul, P.; Kusari, S.; Spiteller, M. (2010):
"Antibiotikarückstände in Gülle und Böden"
Mitt Umweltchem Ökotox, 2, 41-44.

2. Kusari, S.; Spiteller, M. (2010):
"Do endophyte metabolomics reflect the phytochemical diversity of the host plant? A test of the hypothesis with Hypericum species"
In (ed.) Patro, L. R. Biodiversity Conservation and Management, Discovery Publishing House Pvt. Ltd., New Delhi, India, pp. 1-28.

3. Kusari, S.; Spiteller, M. (2010):
"Lessons from endophytes: Peering under the skin of plants"
In (ed.) Patro, L. R. Biotechnology – Its Growing Dimensions, Sonali Publications, New Delhi, India, pp. 1-27.

4. Awouafack, M.; Kusari, S.; Lamshöft, M.; Ngamga, D.; Tane, P.; Spiteller, M. (2010):
"Semi-synthesis of dihydrochalcone derivatives and their in vitro antimicrobial activities"
Planta Medica, 76, 640-643.

Posters

1. Sohrab, M. H.; Kusari, S.; Lamshöft, M.; Zühlke, S.; Spiteller, M. (2010):
"Bioactive metabolites from medicinal plants of Bangladesh and their associated endophytic fungi"
3rd EuCheMS Chemistry Congress: Chemistry - the Creative Force. August 29 - September 2, 2010, Nürnberg, Germany.

2. Sohrab, M. H.; Kusari, S.; Lamshöft, M.; Zühlke, S.; Spiteller, M. (2010):
"Search for new active metabolites from medicinal plants of Bangladesh and their associated endophytic fungi"
The 3rd. "Tag der Chemie" (Chemistry Day); organized by the Faculty of Chemistry, TU Dortmund, and the JCF Dortmund; venue: TU Dortmund; dated February 05, 2010.

3. Kusari, S.; Zühlke, S.; Lamshöft, M.; Spiteller, M. (2010):
"Endophytes, a promising source of host- specific bioactive compounds: future prospects and challenges"
BIOTRENDS 2010 International Congress - New Biotrends in Green Chemistry; venue: Harenberg City Center (HCC), Dortmund, Germany; dated December 01- 02, 2010.

4. Kusari, S.; Zühlke, S.; Kosuth, J.; Cellarova, E.; Spiteller, M. (2010):
"Endophytic Thielavia subthermophila demonstrates light- independent metabolomics in axenic cultures: what can we say about microbial hypericin biosynthesis in planta"
The 3rd. "Tag der Chemie" (Chemistry Day); organized by the Faculty of Chemistry, TU Dortmund, and the JCF Dortmund; venue: TU Dortmund; dated February 05, 2010.

Lectures

1. Spiteller, M.; Kusari, S.; Zühlke, S.; Lamshöft, M. (2010):
"Bioactive compounds from endophytic fungi: Isolation, analysis and possibilities for biotechnological production"
GDCh-Colloquium, Universität Duisburg-Essen, Germany; on June 02, 2010.

2. Kusari, S.; Zühlke, S.; Lamshöft, M.; Spiteller, M. (2010):
"Bioaktive Verbindungen aus endophytischen Pilzen: Isolierung, Analytik und Möglichkeiten der biotechnologischen Produktion"
Vortrag anlässlich einer GDCh Veranstaltung in Essen, 02.06.2010.

2009


Publications

1. Sukul, P.; Lamshöft, M.; Kusari, S.; Zühlke, S.; Spiteller, M. (2009):
"Metabolism and excretion kinetics of 14C- labeled and non- labeled difloxacin in pigs after oral administration, and antimicrobial activity of manure containing difloxacin and its metabolites"
Environmental Research, 109, 225-231.

2. Kusari, S.; Zühlke, S.; Spiteller, M. (2009):
"An Endophytic Fungus from Camptotheca acuminata that Produces Camptothecin and Analogues"
Journal of Natural Products, 72 (1), 2-7

3. Kusari, S.; Zühlke, S.; Kosuth, J.; Cellarova, E.; Spiteller, M. (2009):
"Light-Independent Metabolomics of Endophytic Thielavia subthermophila Provides Insight into Microbial Hypericin Biosynthesis"
Journal of Natural Products, 72, 1825-1835.

4. Kusari, S.; Zühlke, S.; Borsch, T.; Spiteller, M. (2009):
"Positive correlations between hypericin and putative precursors detected in the quantitative secondary metabolite spectrum of Hypericum"
Phytochemistry, 70, 1222-1232.

5. Kusari, S.; Lamshöft, M.; Spiteller, M. (2009):
"Aspergillus fumigatus Fresenius, an endophytic fungus from Juniperus communis L. Horstmann as a novel source of the anticancer pro-drug deoxypodophyllotoxin"
Journal of Applied Microbiology, 107, 1019-1030.

6. Kusari, S.; Deivasigamani, P.; Lamshöft, M.; Spiteller, M. (2009):
"In Vitro Residual Anti-bacterial Activity of Difloxacin, Sarafloxacin and their Photoproducts after Photolysis in Water"
Environmental Pollution, 157, 2722-2730.

Lectures

1. Spiteller, M.; Kusari, S.; Zühlke, S.; Lamshöft, M. (2009):
"Endophytes as a promising source of bioactive compounds used in traditional medicine: future prospects and challenges"
Cameroon, Nov 30, 2009 to Dec 16, 2009.

2. Spiteller, M.; Kusari, S.; Zühlke, S. (2009):
"Formation and structural elucidation of biological active compounds from endophytic fungi"
Sofia University "St. Kl. Ohridski", Faculty of Chemistry, 20th January, 2009.

3. Spiteller, M.; Kusari, S.; Lamshöft, M.; Zühlke, S. (2009):
"Formation and structural elucidation of biologically active compounds from endophytic fungi"
Budapest University of Technology and Economics, Department of Inorganic and Analytical Chemistry, Budapest, Hungary, 09th February, 2009.

4. Spiteller, M.; Kusari, S.; Zühlke, S.; Lamshöft, M. (2009):
"Endophytes, a promising source of bioactive compounds used in traditional medicine: future prospects and challenges"
Alexander Humboldt Foundation International Meet, Beijing, P.R. China, September 24, 2009 - October 02, 2009.

5. Lamshöft, M.;Deivasigamani, P.; Kusari, S.; Sukul, P.; Zühlke, S.;Spiteller, M. (2009):
"Metabolismus, Verbleib und residuale antibakterielle Aktivität von Difloxacin in Gülle, Boden und Wasser"
Jahrestagung der Fachgruppe Umweltchemie und Ökotoxikologie 2009 Trier 23-25.09.2009.

6. Kusari, S.; Zühlke, S.; Spiteller, M. (2009):
"Endophytes as hidden treasures within the botanical richness of nature: Camptotheca acuminata as an example", ESF-COST High-Level Research Conference - "Natural Products Chemistry, Biology and Medicine II"
Acquafredda di Maratea (near Naples), Italy, 29 August - 3 September 2009.

2008


Publications

1. Kusari, S.; Lamshöft, M.; Zühlke, S.; Spiteller, M. (2008):
"An Endophytic Fungus from Hypericum perforatum that Produces Hypericin"
Journal of Natural Products, 71 (2), 159-162.

Posters

1. Kusari, S.; Zühlke, S.; Spiteller, M. (2008):
"Attenuation of camptothecin and 9-methoxycamptothecin production by endophytic Fusarium solani over generations: a possible indication of a split biosynthetic pathway", International Conference on "Emerging Trends in Biological Sciences" - at KIIT School of Biotechnology, KIIT University, Bhubaneshwar, Orissa, India - on 24-25 October 2008.

2. Kusari, S.; Lamshöft, M.; Zühlke, S.; Spiteller, M. (2008):
"Thielavia subthermophila, an endophytic fungus from Hypericum perforatum L. as a novel source of hypericin and its probable precursor emodin", International Conference on "Emerging Trends in Biological Sciences" - at KIIT School of Biotechnology, KIIT University, Bhubaneshwar, Orissa, India - on 24-25 October 2008

Lectures

1. Kusari, S.; Zühlke, S.; Spiteller, M. (2008):
"Prospecting for novel bioactive molecules from endophytic fungi isolated from Camptotheca acuminata"
At BOEHRINGER INGELHEIM GMBH, GERMANY - 18 November 2008.

2. Kusari, S.; Zühlke, S.; Spiteller, M. (2008):
"An endophytic Fusarium solani as a novel source of antineoplastic camptothecin and its 9-methoxy and 10-hydroxy derivatives"
University of Agricultural Sciences (UAS), Bangalore, India - 07-15 November 2008 - within the INDO-German (BMBF/DLR-DBT) Collaboration.

3. Kusari, S.; Zühlke, S.; Spiteller, M. (2008):
"An endophytic fungus as a novel source of antineoplastic camptothecin and its methoxy and hydroxy analogues"
International Conference on "Emerging Trends in Biological Sciences" - at KIIT School of Biotechnology, KIIT University, Bhubaneshwar, Orissa, India - on 24-25 October 2008.

4. Kusari, S.; Spiteller, M. (2008):
"Lessons from Endophytes-Peering under the skin of plants"
INTERNATIONAL SCIENTIFIC COLLOQUIUM 2008, NOVISAD, R. SERBIA - 02-05 October 2008 - Funded by DAAD, under Stability Pact for South Eastern Europe.

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