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Stereogenic Nitrogen Centres with Specific Configurations - Dr. Prisca Eckert

The configuration of stereogenic nitrogen centres that contain a free electron pair is usually not stable due to the low barrier of inversion. We investigate different possibilities of fixing one specific configuration at stereogenic nitrogen centres of chiral diamines by exploring the following methods:
1. The coordination to transition metals[1]  

koord2

 

silazanco4

molecular structure in the crystal

2. Ring closure reactions  

Umkristallisation2

rechnung2

calculated transition state

 

 

[1] Formation of Specific Configurations at Stereogenic Nitrogen Centers upon their Coordination to Zinc and Mercury: P.K. Eckert, V.H. Gessner, M. Knorr, C. Strohmann, Inorg. Chem. 2012, 51, 8516-8523.